361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
The paper introduces SPEx, a cost-effective method that combines expansion microscopy with laser microdissection and mass spectrometry to achieve high-resolution subcellular proteomics, successfully identifying known and novel components of organelles like the Golgi, nucleus, and nucleoli.
This study reveals that non-taste GPCRs exhibit functional diversity in interacting with gustducin, either activating it or forming unproductive complexes that suppress basal signaling and sequester receptors from alternative pathways, thereby establishing a novel mechanism for balancing concurrent cellular signaling.
This study reveals that translational stress triggers UFMylation of ER-associated ribosomes to anchor splicing factors at the endoplasmic reticulum, thereby depleting their nuclear pools and reprogramming nuclear splicing to specifically alter the expression of membrane lipid metabolism genes as a conserved retrograde signaling mechanism.
This study demonstrates that SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to generate linear actin filaments, thereby regulating the architecture and protrusion efficiency of lamellipodia in migrating cells.
This study introduces a shotgun single-cell top-down proteomics strategy that successfully profiles diverse proteoforms in individual mouse cardiomyocytes, revealing substantial cell-to-cell molecular heterogeneity and establishing a powerful tool for understanding cardiac cellular identity and physiology.
This study identifies VIA1 as an evolutionarily conserved regulator that maintains thylakoid membrane integrity under high light stress by directly binding to and functioning with the ESCRT-III-like protein VIPP1.
This paper demonstrates that spatial heterogeneities in minimal stochastic reaction-diffusion models are sufficient to fundamentally reshape cell polarization dynamics, explaining phenomena like pole-to-pole oscillations and the New-End Take-Off through mechanisms of stochastic competition and finite cytoplasmic diffusion without requiring complex biochemical motifs.
This study demonstrates that in larval zebrafish, pharmacological vasodilation significantly reduces intracerebral haematoma size by confining red blood cells to affected vessels, whereas vasoconstriction does not exacerbate haemorrhage, thereby establishing vascular dilation as a key modulator of haemorrhage progression.
This study reveals that inhibiting V-ATPase triggers GCN1/GCN2-mediated integrated stress response and rapid MCL-1 depletion, leading to BAX/BAK-dependent apoptosis and creating a therapeutic vulnerability that synergizes with BH3 mimetics in MCL-1-dependent cancers.
This study reveals that axonal development relies on a novel Golgi-independent pathway where the axonal endoplasmic reticulum couples local transmembrane protein translation and secretion through a feedback loop involving HDLBP and the NRZ-SEC22B tethering complex to facilitate protein delivery to the axonal plasma membrane.