📄 Category

cell biology

414 papers

Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.

At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.

📄 cell biology

Crosstalk Between Calcium Dynamics and ROS Levels in U87 Glioblastoma Cells Exposed to Extremely Low Frequency Pulsed Electromagnetic Fields

This study demonstrates that in U87 glioblastoma cells, exposure to extremely low-frequency pulsed electromagnetic fields triggers an early, frequency-dependent increase in reactive oxygen species (ROS) that acts as a primary mediator to modulate mitochondrial function and downstream calcium signaling, independent of IP3-mediated ER calcium release.

Hadichgeni, S., Shariatpanahi, S. P., Goliaei, B., H. Sajedi, R., Same-Majandeh, A., Salehi, F., Nezamtaheri, M. S.2026-04-18
📄 cell biology

Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation

This study demonstrates that physiologically relevant cooling triggers a reversible, cell-autonomous decrease in global protein acetylation and a selective remodeling of the mitochondrial acetylome in white adipocytes, thereby enhancing mitochondrial function and metabolic adaptation independent of changes in acetyltransferase/deacetylase expression or acetyl-CoA availability.

Mori, H., Hariri, H., Moe, W., Durham, S., Guzman, Y., Paulsson, E., Simmermon, R., Bhanderi, P., Peterson, S., Dickson (…)2026-04-17
📄 cell biology

Expansion and Differentiation of Adult Human Pancreas-Derived Progenitor Cells into Functional Islet-Like Organoids

This study establishes a clinically compatible workflow for expanding and differentiating adult human pancreas-derived progenitor cells, specifically CD81+/CD9+ populations isolated from non-endocrine tissue fractions, into functional islet-like organoids capable of glucose-regulated hormone secretion, offering a potential autologous source for diabetes cell replacement therapies.

Kuncha, J., Darden, C. M., Kirkland, J. T., Blanck, J.-P., Fowlds, K., Cho, M., Danobeitia, J. S., Naziruddin, B., Lawre (…)2026-04-17
📄 cell biology

Determinants of CCT motif specificity in WNK signaling and expansion of CCT like domains

This study elucidates the structural and physicochemical determinants governing CCT domain specificity in WNK signaling, revealing distinct binding classes, a novel motif for the second WNK CCT domain, and the existence of a similar FERRY3 domain, thereby establishing a broader framework for understanding these protein-protein interactions.

Magana-Avila, G., Rojas-Ortega, E., Lira-Castaneda, M., Diaz-Ortiz, I., Bustamante, J., Carbajal-Contreras, H., Rojas-Ju (…)2026-04-17
📄 cell biology

Bulk delivery of a preassembled apical surface initiates epithelial lumen formation

This study reveals that epithelial lumen formation is initiated by the bulk delivery of preassembled, microvilli-rich vacuolar apical compartments (VACs) to the apical membrane initiation site, a process coordinated by the Crumbs complex protein PatJ to ensure rapid and efficient lumenogenesis.

Ghosh, S., Martin, E., Chen, Y., Amiera, N., Singh, S., Low, K. E., Girardello, R., Huebner, B., Dittmar, G., Ludwig, A.2026-04-15